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-Structure paper
Title | Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. |
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Journal, issue, pages | Bioorg. Chem., Vol. 101, Page 103901-103901, Year 2020 |
Publish date | Apr 30, 2020 (structure data deposition date) |
![]() | Kim, D. / Kim, S.Y. / Yoon, N.G. / Yun, J. / Hong, K.B. / Lee, C. / Lee, J.H. / Kang, B.H. / Kang, S. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.7 - 2.59 Å |
Structure data | ![]() PDB-7c04: ![]() PDB-7c05: |
Chemicals | ![]() ChemComp-FEU: ![]() ChemComp-HOH: ![]() ChemComp-FE6: |
Source |
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![]() | CHAPERONE / TRAP1 / selectivity / mitochondria / Hsp90 / Anticancer / Drug |