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-Structure paper
Title | Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 127475-127475, Year 2020 |
Publish date | Apr 3, 2020 (structure data deposition date) |
![]() | Katayama, K. / Ishii, K. / Tsuda, E. / Yotsumoto, K. / Hiramoto, K. / Suzuki, M. / Yasumatsu, I. / Igarashi, W. / Torihata, M. / Ishiyama, T. / Katagiri, T. |
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Methods | X-ray diffraction |
Resolution | 2 - 2.6 Å |
Structure data | ![]() PDB-7btv: ![]() PDB-7buc: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-SAM: ![]() ChemComp-N47: ![]() ChemComp-HOH: ![]() ChemComp-F80: |
Source |
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![]() | TRANSFERASE / PROTEIN-SMALL MOLECULE INHIBITOR COMPLEX / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / TRANSFERASE/TRANSFERASE INHIBITOR |