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Structure paper

TitleStructural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
Journal, issue, pagesNat Commun, Vol. 11, Page 4578-4578, Year 2020
Publish dateMar 25, 2020 (structure data deposition date)
AuthorsFurihata, H. / Yamanaka, S. / Honda, T. / Miyauchi, Y. / Asano, A. / Shibata, N. / Tanokura, M. / Sawasaki, T. / Miyakawa, T.
External linksNat Commun / PubMed:32929090
MethodsX-ray diffraction
Resolution1.8 - 1.9 Å
Structure data

PDB-7bqu:
Cereblon in complex with SALL4 and (S)-thalidomide
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-7bqv:
Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-EF2:
S-Thalidomide / medication*YM

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-F4U:
2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsMETAL BINDING PROTEIN / ZINC FINGER / E3 UBIQUITIN LIGASE / COMPLEX / THALIDOMIDE

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