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TitleDiscovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension.
Journal, issue, pagesActa Pharm Sin B, Vol. 10, Page 2339-2347, Year 2020
Publish dateMar 22, 2020 (structure data deposition date)
AuthorsYang, Y. / Zhang, S. / Zhou, Q. / Zhang, C. / Gao, Y. / Wang, H. / Li, Z. / Wu, D. / Wu, Y. / Huang, Y.Y. ...Yang, Y. / Zhang, S. / Zhou, Q. / Zhang, C. / Gao, Y. / Wang, H. / Li, Z. / Wu, D. / Wu, Y. / Huang, Y.Y. / Guo, L. / Luo, H.B.
External linksActa Pharm Sin B / PubMed:33354505
MethodsX-ray diffraction
Resolution2.40008632403 Å
Structure data

PDB-7bpi:
The crystal structue of PDE10A complexed with 14
Method: X-RAY DIFFRACTION / Resolution: 2.40008632403 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-DZU:
8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE10A inhibitor

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