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-Structure paper
Title | Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration. |
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Journal, issue, pages | Rsc Chem Biol, Vol. 2, Page 612-626, Year 2021 |
Publish date | Mar 19, 2020 (structure data deposition date) |
Authors | Nielsen, A.L. / Rajabi, N. / Kudo, N. / Lundo, K. / Moreno-Yruela, C. / Baek, M. / Fontenas, M. / Lucidi, A. / Madsen, A.S. / Yoshida, M. / Olsen, C.A. |
External links | Rsc Chem Biol / PubMed:34458803 |
Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | PDB-7bos: PDB-7bot: |
Chemicals | ChemComp-ZN: ChemComp-F4R: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / NAD-dependent deacetylase / deacylase / inhibitor complex / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |