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TitleHarnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities
Journal, issue, pagesNat Commun, Year 2021
Publish dateDec 3, 2020 (structure data deposition date)
AuthorsAlbers S / Beckert B / Wilson ND / Ignatova Z
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.9 Å
Structure data

12035

7b5k

EMDB-12035, PDB-7b5k:
E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ERY:
ERYTHROMYCIN A / antibiotic*YM

ChemComp-SY5:
2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid

ChemComp-HOH:
WATER

Source
  • escherichia coli k-12 (bacteria)
KeywordsRIBOSOME / Cryo-EM / 70S / P-site tRNA / E-site tRNA / Erythromycin / N6-(3aminopropyl)-negamycin / Antibiotics

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