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-Structure paper
Title | Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i). |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 10230-10245, Year 2021 |
Publish date | Nov 23, 2020 (structure data deposition date) |
![]() | Klein, M. / Busch, M. / Friese-Hamim, M. / Crosignani, S. / Fuchss, T. / Musil, D. / Rohdich, F. / Sanderson, M.P. / Seenisamy, J. / Walter-Bausch, G. ...Klein, M. / Busch, M. / Friese-Hamim, M. / Crosignani, S. / Fuchss, T. / Musil, D. / Rohdich, F. / Sanderson, M.P. / Seenisamy, J. / Walter-Bausch, G. / Zanelli, U. / Hewitt, P. / Esdar, C. / Schadt, O. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.43 Å |
Structure data | ![]() PDB-7b12: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-NA: ![]() ChemComp-SKN: ![]() ChemComp-HOH: |
Source |
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![]() | IMMUNE SYSTEM / MULTICATALYTIC PROTEINASE / 20S PROTEASOME / PROTEASE / HYDROLASE |