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Title | 4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 14620-14646, Year 2021 |
Publish date | Nov 10, 2020 (structure data deposition date) |
Authors | Schaker-Hubner, L. / Warstat, R. / Ahlert, H. / Mishra, P. / Kraft, F.B. / Schliehe-Diecks, J. / Scholer, A. / Borkhardt, A. / Breit, B. / Bhatia, S. ...Schaker-Hubner, L. / Warstat, R. / Ahlert, H. / Mishra, P. / Kraft, F.B. / Schliehe-Diecks, J. / Scholer, A. / Borkhardt, A. / Breit, B. / Bhatia, S. / Hugle, M. / Gunther, S. / Hansen, F.K. |
External links | J. Med. Chem. / PubMed:34582215 |
Methods | X-ray diffraction |
Resolution | 1.5 Å |
Structure data | PDB-7axr: |
Chemicals | ChemComp-S7T: ChemComp-HOH: |
Source |
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Keywords | PROTEIN BINDING / BRD4(1) / BRD4 / BD1 / first Bromodomain / Bromodomain / BET / HDAC / BETi / HDACi / dual Inhibitor / LSH24 |