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TitleReducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System.
Journal, issue, pagesSLAS Discov, Vol. 26, Page 663-675, Year 2021
Publish dateNov 9, 2020 (structure data deposition date)
AuthorsGreenhough, L.A. / Clarke, G. / Phillipou, A.N. / Mazani, F. / Karamshi, B. / Rowe, S. / Rowland, P. / Messenger, C. / Haslam, C.P. / Bingham, R.P. / Craggs, P.D.
External linksSLAS Discov / PubMed:33783261
MethodsX-ray diffraction
Resolution2.12 Å
Structure data

PDB-7ax4:
Human TYK2 pseudokinase domain (575-869) in complex with 5-(4-Fluoro-phenyl)-2-ureido-thiophene-3-carboxylic acid amide.
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

Chemicals

ChemComp-NM7:
2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / TYK2 PSEUDOKINASE TPCA-1

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