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TitleMETTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes.
Journal, issue, pagesChemmedchem, Vol. 16, Page 3035-3043, Year 2021
Publish dateSep 10, 2020 (structure data deposition date)
AuthorsMoroz-Omori, E.V. / Huang, D. / Kumar Bedi, R. / Cheriyamkunnel, S.J. / Bochenkova, E. / Dolbois, A. / Rzeczkowski, M.D. / Li, Y. / Wiedmer, L. / Caflisch, A.
External linksChemmedchem / PubMed:34237194
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-7acd:
Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1a)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-R72:
4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide

ChemComp-MG:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inhibitor / Complex / METTL3 / Sinefungin / METTL14

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