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TitleRibosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
Journal, issue, pagesNucleic Acids Res., Vol. 49, Page 9560-9573, Year 2021
Publish dateAug 10, 2020 (structure data deposition date)
AuthorsBreiner-Goldstein, E. / Eyal, Z. / Matzov, D. / Halfon, Y. / Cimicata, G. / Baum, M. / Rokney, A. / Ezernitchi, A.V. / Lowell, A.N. / Schmidt, J.J. ...Breiner-Goldstein, E. / Eyal, Z. / Matzov, D. / Halfon, Y. / Cimicata, G. / Baum, M. / Rokney, A. / Ezernitchi, A.V. / Lowell, A.N. / Schmidt, J.J. / Rozenberg, H. / Zimmerman, E. / Bashan, A. / Valinsky, L. / Anzai, Y. / Sherman, D.H. / Yonath, A.
External linksNucleic Acids Res. / PubMed:34417608
MethodsX-ray diffraction
Resolution3.22 - 3.4 Å
Structure data

PDB-7a0r:
50S Deinococcus radiodurans ribosome bounded with mycinamicin I
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-7a0s:
50S Deinococcus radiodurans ribosome bounded with mycinamicin I
Method: X-RAY DIFFRACTION / Resolution: 3.22 Å

PDB-7a18:
50S Deinococcus radiodurans ribosome bounded with mycinamicin IV
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-QTZ:
mycinamicin II

ChemComp-MG:
Unknown entry

ChemComp-QU2:
mycinamicin I

ChemComp-SPD:
SPERMIDINE

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-NA:
Unknown entry

ChemComp-EOH:
ETHANOL

ChemComp-CA:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-MIV:
MYCINAMICIN IV

Source
  • deinococcus radiodurans r1 (radioresistant)
KeywordsANTIBIOTIC / Complex / NPET / Macrolide / A2058

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