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Structure paper

TitleStructural Insights into PROTAC-Mediated Degradation of Bcl-xL.
Journal, issue, pagesAcs Chem. Biol., Vol. 15, Page 2316-2323, Year 2020
Publish dateJun 22, 2020 (structure data deposition date)
AuthorsChung, C.W. / Dai, H. / Fernandez, E. / Tinworth, C.P. / Churcher, I. / Cryan, J. / Denyer, J. / Harling, J.D. / Konopacka, A. / Queisser, M.A. ...Chung, C.W. / Dai, H. / Fernandez, E. / Tinworth, C.P. / Churcher, I. / Cryan, J. / Denyer, J. / Harling, J.D. / Konopacka, A. / Queisser, M.A. / Tame, C.J. / Watt, G. / Jiang, F. / Qian, D. / Benowitz, A.B.
External linksAcs Chem. Biol. / PubMed:32697072
MethodsX-ray diffraction
Resolution1.92 Å
Structure data

PDB-6zhc:
PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

Chemicals

ChemComp-QL8:
2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PROTAC complex / targeted degradation / ubiquitin ligase / bifunctional ligand / E3 ligase / Bcl-xL

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