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| Title | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 63, Page 15564-15590, Year 2020 |
| Publish date | May 22, 2020 (structure data deposition date) |
 Authors | Barlaam, B. / Casella, R. / Cidado, J. / Cook, C. / De Savi, C. / Dishington, A. / Donald, C.S. / Drew, L. / Ferguson, A.D. / Ferguson, D. ...Barlaam, B. / Casella, R. / Cidado, J. / Cook, C. / De Savi, C. / Dishington, A. / Donald, C.S. / Drew, L. / Ferguson, A.D. / Ferguson, D. / Glossop, S. / Grebe, T. / Gu, C. / Hande, S. / Hawkins, J. / Hird, A.W. / Holmes, J. / Horstick, J. / Jiang, Y. / Lamb, M.L. / McGuire, T.M. / Moore, J.E. / O'Connell, N. / Pike, A. / Pike, K.G. / Proia, T. / Roberts, B. / San Martin, M. / Sarkar, U. / Shao, W. / Stead, D. / Sumner, N. / Thakur, K. / Vasbinder, M.M. / Varnes, J.G. / Wang, J. / Wang, L. / Wu, D. / Wu, L. / Yang, B. / Yao, T. |
 External links | J. Med. Chem. / PubMed:33306391 |
| Methods | X-ray diffraction |
| Resolution | 3.37 Å |
| Structure data |  PDB-6z45: |
| Chemicals |  ChemComp-Q6E:  ChemComp-TRS:  ChemComp-PO4: |
| Source |
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 Keywords | TRANSFERASE / Inhibitor / complex / kinase |
homo sapiens (human)