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-Structure paper
Title | Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 5816-5840, Year 2020 |
Publish date | Apr 18, 2020 (structure data deposition date) |
Authors | Clegg, M.A. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Gordon, L. / Grandi, P. / Leveridge, M. / Lindon, M. / Liwicki, G.M. / Michon, A.M. ...Clegg, M.A. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Gordon, L. / Grandi, P. / Leveridge, M. / Lindon, M. / Liwicki, G.M. / Michon, A.M. / Molnar, J. / Rioja, I. / Soden, P.E. / Theodoulou, N.H. / Werner, T. / Tomkinson, N.C.O. / Prinjha, R.K. / Humphreys, P.G. |
External links | J. Med. Chem. / PubMed:32410449 |
Methods | X-ray diffraction |
Resolution | 1.39 - 1.684 Å |
Structure data | PDB-6yqr: PDB-6yqs: PDB-6yqw: PDB-6yqz: |
Chemicals | ChemComp-P8W: ChemComp-HOH: ChemComp-P8Z: ChemComp-82I: ChemComp-EDO: |
Source |
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Keywords | TRANSCRIPTION / BRD9 / INHIBITOR / HISTONE / EPIGENETIC READER / BROMODOMAIN / BRD4 |