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-Structure paper
Title | Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite. |
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Journal, issue, pages | Acs Infect Dis., Vol. 6, Page 1098-1109, Year 2020 |
Publish date | Feb 16, 2020 (structure data deposition date) |
Authors | Cunningham, F. / Esquivias, J. / Fernandez-Menendez, R. / Perez, A. / Guardia, A. / Escribano, J. / Rivero, C. / Vimal, M. / Cacho, M. / de Dios-Anton, P. ...Cunningham, F. / Esquivias, J. / Fernandez-Menendez, R. / Perez, A. / Guardia, A. / Escribano, J. / Rivero, C. / Vimal, M. / Cacho, M. / de Dios-Anton, P. / Martinez-Martinez, M.S. / Jimenez, E. / Huertas Valentin, L. / Rebollo-Lopez, M.J. / Lopez-Roman, E.M. / Sousa-Morcuende, V. / Rullas, J. / Neu, M. / Chung, C.W. / Bates, R.H. |
External links | Acs Infect Dis. / PubMed:32196311 |
Methods | X-ray diffraction |
Resolution | 1.533 - 2.886 Å |
Structure data | PDB-6y2i: PDB-6y2j: |
Chemicals | ChemComp-EDO: ChemComp-O6Z: ChemComp-NA: ChemComp-PG4: ChemComp-HOH: ChemComp-O6W: |
Source |
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Keywords | TRANSFERASE / INHIBITOR / KASA / MYCOBACTERIUM TUBERCULOSIS / 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1 / ACYLTRANSFERASE / LIPID SYNTHESIS / FATTY ACID BIOSYNTHESIS |