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-Structure paper
Title | Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 6876-6897, Year 2020 |
Publish date | Feb 3, 2020 (structure data deposition date) |
Authors | Liu, Y. / Wu, J. / Zhou, M. / Chen, W. / Li, D. / Wang, Z. / Hornsperger, B. / Aebi, J.D. / Marki, H.P. / Kuhn, B. ...Liu, Y. / Wu, J. / Zhou, M. / Chen, W. / Li, D. / Wang, Z. / Hornsperger, B. / Aebi, J.D. / Marki, H.P. / Kuhn, B. / Wang, L. / Kuglstatter, A. / Benz, J. / Muller, S. / Hochstrasser, R. / Ottaviani, G. / Xin, J. / Kirchner, S. / Mohr, S. / Verry, P. / Riboulet, W. / Shen, H.C. / Mayweg, A.V. / Amrein, K. / Tan, X. |
External links | J. Med. Chem. / PubMed:32530624 |
Methods | X-ray diffraction |
Resolution | 2.77 - 3 Å |
Structure data | PDB-6xz8: PDB-6xz9: |
Chemicals | ChemComp-HEC: ChemComp-O4T: ChemComp-HOH: ChemComp-O4W: |
Source |
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Keywords | OXIDOREDUCTASE / CYTOCHROME P450 / CYP11B2 / ALDOSTERONE SYNTHASE |