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| Title | Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. |
|---|---|
| Journal, issue, pages | Embo J., Vol. 39, Page e106275-e106275, Year 2020 |
| Publish date | Jun 4, 2020 (structure data deposition date) |
 Authors | Klemm, T. / Ebert, G. / Calleja, D.J. / Allison, C.C. / Richardson, L.W. / Bernardini, J.P. / Lu, B.G. / Kuchel, N.W. / Grohmann, C. / Shibata, Y. ...Klemm, T. / Ebert, G. / Calleja, D.J. / Allison, C.C. / Richardson, L.W. / Bernardini, J.P. / Lu, B.G. / Kuchel, N.W. / Grohmann, C. / Shibata, Y. / Gan, Z.Y. / Cooney, J.P. / Doerflinger, M. / Au, A.E. / Blackmore, T.R. / van der Heden van Noort, G.J. / Geurink, P.P. / Ovaa, H. / Newman, J. / Riboldi-Tunnicliffe, A. / Czabotar, P.E. / Mitchell, J.P. / Feltham, R. / Lechtenberg, B.C. / Lowes, K.N. / Dewson, G. / Pellegrini, M. / Lessene, G. / Komander, D. |
 External links | Embo J. / PubMed:32845033 |
| Methods | X-ray diffraction |
| Resolution | 2.7 - 2.9 Å |
| Structure data |  PDB-6xa9:  PDB-6xaa: |
| Chemicals |  ChemComp-GOL:  ChemComp-ZN:  ChemComp-HOH: |
| Source |
|
 Keywords | HYDROLASE/SUBSTRATE / SARS CoV-2 / papain-like protease / ISG15CTD activity based probe / COVID19 / HYDROLASE-SUBSTRATE complex / ubiquitin activity based probe |
severe acute respiratory syndrome coronavirus 2
homo sapiens (human)