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-Structure paper
Title | Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. |
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Journal, issue, pages | Commun Biol, Vol. 4, Page 193-193, Year 2021 |
Publish date | Apr 19, 2020 (structure data deposition date) |
Authors | Kim, Y. / Wower, J. / Maltseva, N. / Chang, C. / Jedrzejczak, R. / Wilamowski, M. / Kang, S. / Nicolaescu, V. / Randall, G. / Michalska, K. / Joachimiak, A. |
External links | Commun Biol / PubMed:33564093 |
Methods | X-ray diffraction |
Resolution | 1.82 - 2.25 Å |
Structure data | PDB-6wlc: PDB-6wxc: PDB-6x1b: PDB-6x4i: PDB-7k1l: |
Chemicals | ChemComp-U5P: ChemComp-TRS: ChemComp-EDO: ChemComp-ACT: ChemComp-SO4: ChemComp-FMT: ChemComp-HOH: ChemComp-CMU: ChemComp-PO4: ChemComp-U3P: ChemComp-NA: ChemComp-UVC: |
Source |
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Keywords | VIRAL PROTEIN / SARS Corona virus 2 / endoribonuclease / COVID-19 / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID / refurbishing drug |