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TitleTipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Journal, issue, pagesCommun Biol, Vol. 4, Page 193-193, Year 2021
Publish dateApr 19, 2020 (structure data deposition date)
AuthorsKim, Y. / Wower, J. / Maltseva, N. / Chang, C. / Jedrzejczak, R. / Wilamowski, M. / Kang, S. / Nicolaescu, V. / Randall, G. / Michalska, K. / Joachimiak, A.
External linksCommun Biol / PubMed:33564093
MethodsX-ray diffraction
Resolution1.82 - 2.25 Å
Structure data

PDB-6wlc:
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-5'-Monophosphate
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-6wxc:
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with potential repurposing drug Tipiracil
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6x1b:
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with the Product Nucleotide GpU.
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-6x4i:
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with 3'-uridinemonophosphate
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-7k1l:
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-2',3'-Vanadate
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

ChemComp-CMU:
5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-U3P:
3'-URIDINEMONOPHOSPHATE

ChemComp-NA:
Unknown entry

ChemComp-UVC:
URIDINE-2',3'-VANADATE

Source
  • severe acute respiratory syndrome coronavirus 2
  • synthetic construct (others)
KeywordsVIRAL PROTEIN / SARS Corona virus 2 / endoribonuclease / COVID-19 / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID / refurbishing drug

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