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Title | Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. |
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Journal, issue, pages | Cancer Res., Vol. 80, Page 4840-4853, Year 2020 |
Publish date | May 4, 2020 (structure data deposition date) |
Authors | Sun, Y. / Meyers, B.A. / Czako, B. / Leonard, P. / Mseeh, F. / Harris, A.L. / Wu, Q. / Johnson, S. / Parker, C.A. / Cross, J.B. ...Sun, Y. / Meyers, B.A. / Czako, B. / Leonard, P. / Mseeh, F. / Harris, A.L. / Wu, Q. / Johnson, S. / Parker, C.A. / Cross, J.B. / Di Francesco, M.E. / Bivona, B.J. / Bristow, C.A. / Burke, J.P. / Carrillo, C.C. / Carroll, C.L. / Chang, Q. / Feng, N. / Gao, G. / Gera, S. / Giuliani, V. / Huang, J.K. / Jiang, Y. / Kang, Z. / Kovacs, J.J. / Liu, C.Y. / Lopez, A.M. / Ma, X. / Mandal, P.K. / McAfoos, T. / Miller, M.A. / Mullinax, R.A. / Peoples, M. / Ramamoorthy, V. / Seth, S. / Spencer, N.D. / Suzuki, E. / Williams, C.C. / Yu, S.S. / Zuniga, A.M. / Draetta, G.F. / Marszalek, J.R. / Heffernan, T.P. / Kohl, N.E. / Jones, P. |
External links | Cancer Res. / PubMed:32928921 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-6wu8: |
Chemicals | ChemComp-U9Y: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / Phosphatase / Inhibitor / Complex / HYDROLASE-HYDROLASE INHIBITOR complex |