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-Structure paper
Title | Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. |
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Journal, issue, pages | J. Biol. Chem., Vol. 299, Page 102999-102999, Year 2023 |
Publish date | Feb 24, 2017 (structure data deposition date) |
Authors | Petrunak, E.M. / Bart, A.G. / Peng, H.M. / Auchus, R.J. / Scott, E.E. |
External links | J. Biol. Chem. / PubMed:36773804 |
Methods | X-ray diffraction |
Resolution | 1.85 - 2.7 Å |
Structure data | PDB-5uys: PDB-6wr0: PDB-6wr1: PDB-6ww0: |
Chemicals | ChemComp-HEM: ChemComp-8QD: ChemComp-HOH: ChemComp-U7P: ChemComp-CL: ChemComp-AER: ChemComp-UDJ: |
Source |
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Keywords | OXIDOREDUCTASE / Steroidogenic / Cytochrome P450 / P450 / 17A1 |