+Search query
-Structure paper
Title | Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer. |
---|---|
Journal, issue, pages | Acs Med. Chem. Lett., Vol. 11, Page 1342-1347, Year 2020 |
Publish date | Apr 24, 2020 (structure data deposition date) |
Authors | Liang, J. / Blake, R. / Chang, J. / Friedman, L.S. / Goodacre, S. / Hartman, S. / Ingalla, E.R. / Kiefer, J.R. / Kleinheinz, T. / Labadie, S. ...Liang, J. / Blake, R. / Chang, J. / Friedman, L.S. / Goodacre, S. / Hartman, S. / Ingalla, E.R. / Kiefer, J.R. / Kleinheinz, T. / Labadie, S. / Li, J. / Lai, K.W. / Liao, J. / Mody, V. / McLean, N. / Metcalfe, C. / Nannini, M. / Otwine, D. / Ran, Y. / Ray, N. / Roussel, F. / Sambrone, A. / Sampath, D. / Vinogradova, M. / Wai, J. / Wang, T. / Yeap, K. / Young, A. / Zbieg, J. / Zhang, B. / Zheng, X. / Zhong, Y. / Wang, X. |
External links | Acs Med. Chem. Lett. / PubMed:32551022 |
Methods | X-ray diffraction |
Resolution | 2.309 Å |
Structure data | PDB-6wok: |
Chemicals | ChemComp-G9J: ChemComp-U6D: ChemComp-HOH: |
Source |
|
Keywords | NUCLEAR PROTEIN / ERA / antagonist / inverse agonist / receptor / breast cancer / degrader / ligand / estrogen receptor |