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-Structure paper
Title | Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 7226-7242, Year 2020 |
Publish date | Mar 12, 2020 (structure data deposition date) |
![]() | Yang, W. / Wang, Y. / Lai, A. / Clark, C.G. / Corte, J.R. / Fang, T. / Gilligan, P.J. / Jeon, Y. / Pabbisetty, K.B. / Rampulla, R.A. ...Yang, W. / Wang, Y. / Lai, A. / Clark, C.G. / Corte, J.R. / Fang, T. / Gilligan, P.J. / Jeon, Y. / Pabbisetty, K.B. / Rampulla, R.A. / Mathur, A. / Kaspady, M. / Neithnadka, P.R. / Arumugam, A. / Raju, S. / Rossi, K.A. / Myers Jr., J.E. / Sheriff, S. / Lou, Z. / Zheng, J.J. / Chacko, S.A. / Bozarth, J.M. / Wu, Y. / Crain, E.J. / Wong, P.C. / Seiffert, D.A. / Luettgen, J.M. / Lam, P.Y.S. / Wexler, R.R. / Ewing, W.R. |
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Methods | X-ray diffraction |
Resolution | 1.95 Å |
Structure data | ![]() PDB-6w50: |
Chemicals | ![]() ChemComp-SWP: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE / SERINE PROTEASE / BLOOD COAGULATION FACTOR / PROTEIN INHIBITOR COMPLEX / HYDROLASE-HYDROLASE INHIBITOR complex |