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TitleStructural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 30, Page 127356-127356, Year 2020
Publish dateMar 11, 2020 (structure data deposition date)
AuthorsYan, N.L. / Santos-Martins, D. / Rennella, E. / Sanchez, B.B. / Chen, J.S. / Kay, L.E. / Wilson, I.A. / Morgan, G.J. / Forli, S. / Kelly, J.W.
External linksBioorg. Med. Chem. Lett. / PubMed:32631553
MethodsX-ray diffraction
Resolution1.91 Å
Structure data

PDB-6w4y:
Structure of full-length human lambda-6A light chain JTO in complex with hydantoin stabilizer
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

Chemicals

ChemComp-7ZW:
2-[(4~{R})-4-(2-methylpropyl)-2,5-bis(oxidanylidene)imidazolidin-1-yl]-~{N}-[4-(trifluoromethyl)phenyl]ethanamide

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / amyloidosis

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