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-Structure paper
Title | Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 6730-6744, Year 2021 |
Publish date | Mar 10, 2020 (structure data deposition date) |
![]() | Lee, E.C.Y. / McRiner, A.J. / Georgiadis, K.E. / Liu, J. / Wang, Z. / Ferguson, A.D. / Levin, B. / von Rechenberg, M. / Hupp, C.D. / Monteiro, M.I. ...Lee, E.C.Y. / McRiner, A.J. / Georgiadis, K.E. / Liu, J. / Wang, Z. / Ferguson, A.D. / Levin, B. / von Rechenberg, M. / Hupp, C.D. / Monteiro, M.I. / Keefe, A.D. / Olszewski, A. / Eyermann, C.J. / Centrella, P. / Liu, Y. / Arora, S. / Cuozzo, J.W. / Zhang, Y. / Clark, M.A. / Huguet, C. / Kohlmann, A. |
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Methods | X-ray diffraction |
Resolution | 1.64 - 1.75 Å |
Structure data | ![]() PDB-6w44: ![]() PDB-6w45: ![]() PDB-6w4c: |
Chemicals | ![]() ChemComp-FMN: ![]() ChemComp-SLJ: ![]() ChemComp-HOH: ![]() ChemComp-SLG: ![]() ChemComp-SL7: |
Source |
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![]() | OXIDOREDUCTASE / Inhibitor / Complex |