Movie
Controller
Structure viewers
About Yorodumi Papers
+Search query
-Structure paper
| Title | Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 11, Page 1402-1409, Year 2020 |
| Publish date | Feb 12, 2020 (structure data deposition date) |
 Authors | Nair, S. / Kumar, S.R. / Paidi, V.R. / Sistla, R. / Kantheti, D. / Polimera, S.R. / Thangavel, S. / Mukherjee, A.J. / Das, M. / Bhide, R.S. ...Nair, S. / Kumar, S.R. / Paidi, V.R. / Sistla, R. / Kantheti, D. / Polimera, S.R. / Thangavel, S. / Mukherjee, A.J. / Das, M. / Bhide, R.S. / Pitts, W.J. / Murugesan, N. / Dudhgoankar, S. / Nagar, J. / Subramani, S. / Mazumder, D. / Carman, J.A. / Holloway, D.A. / Li, X. / Fereshteh, M.P. / Ruepp, S. / Palanisamy, K. / Mariappan, T.T. / Maddi, S. / Saxena, A. / Elzinga, P. / Chimalakonda, A. / Ruan, Q. / Ghosh, K. / Bose, S. / Sack, J. / Yan, C. / Kiefer, S.E. / Xie, D. / Newitt, J.A. / Saravanakumar, S.P. / Rampulla, R.A. / Barrish, J.C. / Carter, P.H. / Hynes Jr., J. |
 External links | Acs Med. Chem. Lett. / PubMed:32676146 |
| Methods | X-ray diffraction |
| Resolution | 2.069 - 2.19 Å |
| Structure data |  PDB-6lxy:  PDB-6vql: |
| Chemicals |  ChemComp-EXF:  ChemComp-SO4:  ChemComp-HOH:  ChemComp-R7S: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / IRAK4 / KINASE / INHIBITOR / CANCER / SIGNALING PROTEIN / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE |
homo sapiens (human)