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-Structure paper
Title | Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 11, Page 1965-1972, Year 2020 |
Publish date | Dec 20, 2019 (structure data deposition date) |
Authors | Ghosh, A.K. / Grillo, A. / Raghavaiah, J. / Kovela, S. / Johnson, M.E. / Kneller, D.W. / Wang, Y.F. / Hattori, S.I. / Higashi-Kuwata, N. / Weber, I.T. / Mitsuya, H. |
External links | Acs Med. Chem. Lett. / PubMed:33062180 |
Methods | X-ray diffraction |
Resolution | 1.18 Å |
Structure data | PDB-6vce: |
Chemicals | ChemComp-NA: ChemComp-CL: ChemComp-G6R: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / ASPARTIC ACID PROTEASE / HIV-1 PROTEASE / cyclic ethers / urethane / carboxamide / inhibitors / multidrug-resistant / synthesis / X-ray crystal structure / backbone binding / VIRAL PROTEIN / HYDROLASE-HYDROLASE INHIBITOR complex |