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TitleDiscovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 11, Page 1899-1904, Year 2020
Publish dateDec 13, 2019 (structure data deposition date)
AuthorsLiu, H. / Niu, D. / Tham Sjin, R.T. / Dubrovskiy, A. / Zhu, Z. / McDonald, J.J. / Fahnoe, K. / Wang, Z. / Munson, M. / Scholte, A. ...Liu, H. / Niu, D. / Tham Sjin, R.T. / Dubrovskiy, A. / Zhu, Z. / McDonald, J.J. / Fahnoe, K. / Wang, Z. / Munson, M. / Scholte, A. / Barrague, M. / Fitzgerald, M. / Liu, J. / Kothe, M. / Sun, F. / Murtie, J. / Ge, J. / Rocnik, J. / Harvey, D. / Ospina, B. / Perron, K. / Zheng, G. / Shehu, E. / D'Agostino, L.A.
External linksAcs Med. Chem. Lett. / PubMed:33062171
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-6v9c:
Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-QS7:
N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / tyrosine Kinase inhibitor / covalent inhibitor / FGFR / kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex

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