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TitleInhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.
Journal, issue, pagesFaseb Bioadv, Vol. 3, Page 334-355, Year 2021
Publish dateNov 15, 2019 (structure data deposition date)
AuthorsLopez-Ramirez, M.A. / McCurdy, S. / Li, W. / Haynes, M.K. / Hale, P. / Francisco, K. / Oukoloff, K. / Bautista, M. / Choi, C.H.J. / Sun, H. ...Lopez-Ramirez, M.A. / McCurdy, S. / Li, W. / Haynes, M.K. / Hale, P. / Francisco, K. / Oukoloff, K. / Bautista, M. / Choi, C.H.J. / Sun, H. / Gongol, B. / Shyy, J.Y. / Ballatore, C. / Sklar, L.A. / Gingras, A.R.
External linksFaseb Bioadv / PubMed:33977234
MethodsX-ray diffraction
Resolution1.924 Å
Structure data

PDB-6uzk:
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6
Method: X-RAY DIFFRACTION / Resolution: 1.924 Å

Chemicals

ChemComp-QMA:
2-hydroxy-6-methoxynaphthalene-1-carbaldehyde

ChemComp-MG:
Unknown entry

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL ADHESION / Complex / Small molecules / GTPase / KRIT1

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