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-Structure paper
| Title | Disruption of IRE1 alpha through its kinase domain attenuates multiple myeloma. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 116, Page 16420-16429, Year 2019 |
| Publish date | Oct 23, 2019 (structure data deposition date) |
 Authors | Harnoss, J.M. / Le Thomas, A. / Shemorry, A. / Marsters, S.A. / Lawrence, D.A. / Lu, M. / Chen, Y.A. / Qing, J. / Totpal, K. / Kan, D. ...Harnoss, J.M. / Le Thomas, A. / Shemorry, A. / Marsters, S.A. / Lawrence, D.A. / Lu, M. / Chen, Y.A. / Qing, J. / Totpal, K. / Kan, D. / Segal, E. / Merchant, M. / Reichelt, M. / Ackerly Wallweber, H. / Wang, W. / Clark, K. / Kaufman, S. / Beresini, M.H. / Laing, S.T. / Sandoval, W. / Lorenzo, M. / Wu, J. / Ly, J. / De Bruyn, T. / Heidersbach, A. / Haley, B. / Gogineni, A. / Weimer, R.M. / Lee, D. / Braun, M.G. / Rudolph, J. / VanWyngarden, M.J. / Sherbenou, D.W. / Gomez-Bougie, P. / Amiot, M. / Acosta-Alvear, D. / Walter, P. / Ashkenazi, A. |
 External links | Proc. Natl. Acad. Sci. U.S.A. / PubMed:31371506 |
| Methods | X-ray diffraction |
| Resolution | 2.2 Å |
| Structure data |  PDB-6urc: |
| Chemicals |  ChemComp-QFV:  ChemComp-GOL:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase / RNase / inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)