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TitleCrystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer
Journal, issue, pagesto be published
Publish dateOct 7, 2019 (structure data deposition date)
AuthorsDranow, D.M. / Abendroth, J. / Lorimer, D.D. / Horanyi, P.S. / Edwards, T.E.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-6uld:
Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-GLY:
GLYCINE

ChemComp-SER:
SERINE

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsTRANSFERASE / SSGCID / Serine hydroxymethyltransferase / Mycobacterium tuberculosis / Pyridoxal phosphate / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease

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