+Search query
-Structure paper
Title | Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 63, Page 1612-1623, Year 2020 |
Publish date | Aug 25, 2019 (structure data deposition date) |
![]() | Caravella, J.A. / Lin, J. / Diebold, R.B. / Campbell, A.M. / Ericsson, A. / Gustafson, G. / Wang, Z. / Castro, J. / Clarke, A. / Gotur, D. ...Caravella, J.A. / Lin, J. / Diebold, R.B. / Campbell, A.M. / Ericsson, A. / Gustafson, G. / Wang, Z. / Castro, J. / Clarke, A. / Gotur, D. / Josephine, H.R. / Katz, M. / Kershaw, M. / Yao, L. / Toms, A.V. / Barr, K.J. / Dinsmore, C.J. / Walker, D. / Ashwell, S. / Lu, W. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.11 Å |
Structure data | ![]() PDB-6u4j: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-CL: ![]() ChemComp-PWV: ![]() ChemComp-FLC: ![]() ChemComp-HOH: |
Source |
|
![]() | Oxidoreductase/Inhibitor / IDH1 / allosteric inhibitor / Oxidoreductase / Inhibitor complex / Oxidoreductase-Inhibitor complex |