EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
ジャーナル・号・ページ	Cell Chem Biol, Vol. 27, Page 32-40.e3, Year 2020
掲載日	2019年8月19日 (構造データの登録日)
著者	Petrilli, W.L. / Adam, G.C. / Erdmann, R.S. / Abeywickrema, P. / Agnani, V. / Ai, X. / Baysarowich, J. / Byrne, N. / Caldwell, J.P. / Chang, W. ...Petrilli, W.L. / Adam, G.C. / Erdmann, R.S. / Abeywickrema, P. / Agnani, V. / Ai, X. / Baysarowich, J. / Byrne, N. / Caldwell, J.P. / Chang, W. / DiNunzio, E. / Feng, Z. / Ford, R. / Ha, S. / Huang, Y. / Hubbard, B. / Johnston, J.M. / Kavana, M. / Lisnock, J.M. / Liang, R. / Lu, J. / Lu, Z. / Meng, J. / Orth, P. / Palyha, O. / Parthasarathy, G. / Salowe, S.P. / Sharma, S. / Shipman, J. / Soisson, S.M. / Strack, A.M. / Youm, H. / Zhao, K. / Zink, D.L. / Zokian, H. / Addona, G.H. / Akinsanya, K. / Tata, J.R. / Xiong, Y. / Imbriglio, J.E.
リンク	Cell Chem Biol / PubMed:31653597
手法	X線回折
解像度	1.53 - 2.73 Å
構造データ	PDB-6u26: PCSK9 in complex with compound 16 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å PDB-6u2n: PCSK9 in complex with compound 4 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-6u2p: PCSK9 in complex with compound 5 手法: X-RAY DIFFRACTION / 解像度: 2.04 Å PDB-6u36: PCSK9 in complex with a Fab and compound 14 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-6u38: PCSK9 in complex with a Fab and compound 8 手法: X-RAY DIFFRACTION / 解像度: 2.73 Å PDB-6u3x: PCSK9 in complex with compound 2 手法: X-RAY DIFFRACTION / 解像度: 2.64 Å
化合物	ChemComp-063: 4'-{[(1R)-6-{2-[2-({N~5~-[N,N'-bis(tert-butoxycarbonyl)carbamimidoyl]-N~2~-(tert-butoxycarbonyl)-L-ornithyl}amino)ethoxy]ethoxy}-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-2'-fluoro[1,1'-biphenyl]-4-carboxylic acid ChemComp-HOH: WATER ChemComp-PV7: 4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid ChemComp-EDO: 1,2-ETHANEDIOL ChemComp-PUV: 2-fluoro-4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid ChemComp-PVM: 2-fluoro-4-{[(1R)-6-(2-{4-[1-(4-methoxyphenyl)-5-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-1H-1,2,3-triazol-1-yl}ethoxy)-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid ChemComp-PVJ: 2-fluoro-4-{[(1R)-1-methyl-6-{[(2S)-oxan-2-yl]methoxy}-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid ChemComp-PVV: 2-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
由来	homo sapiens (ヒト)
キーワード	HYDROLASE/HYDROLASE Inhibitor / CHOLESTEROL CLEARANCE / PCSK9 / LDLR / Autocatalytic cleavage / Cholesterol metabolism / Disulfide bond / Glycoprotein / Hydrolase / Lipid metabolism / Phosphoprotein / Protease / Secreted / Serine protease / inhibitor / HYDROLASE-HYDROLASE Inhibitor complex / Serine Type Endopeptidase Activity Proteolysis / HYDROLASE/Immune System / HYDROLASE-Immune System complex