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Title | Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 8276-8295, Year 2020 |
Publish date | Jan 15, 2020 (structure data deposition date) |
![]() | Knoepfel, T. / Nimsgern, P. / Jacquier, S. / Bourrel, M. / Vangrevelinghe, E. / Glatthar, R. / Behnke, D. / Alper, P.B. / Michellys, P.Y. / Deane, J. ...Knoepfel, T. / Nimsgern, P. / Jacquier, S. / Bourrel, M. / Vangrevelinghe, E. / Glatthar, R. / Behnke, D. / Alper, P.B. / Michellys, P.Y. / Deane, J. / Junt, T. / Zipfel, G. / Limonta, S. / Hawtin, S. / Andre, C. / Boulay, T. / Loetscher, P. / Faller, M. / Blank, J. / Feifel, R. / Betschart, C. |
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Methods | X-ray diffraction |
Resolution | 2.793 Å |
Structure data | ![]() PDB-6ty5: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-O0W: ![]() ChemComp-HOH: |
Source |
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![]() | IMMUNE SYSTEM / RNA recognition Leucine rich repeats Glycosylation Structure based drug design Immune System Innate immunity |