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-Structure paper
Title | Optimization of Orally Bioavailable PI3K delta Inhibitors and Identification of Vps34 as a Key Selectivity Target. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 638-655, Year 2020 |
Publish date | Dec 10, 2019 (structure data deposition date) |
![]() | Henley, Z.A. / Amour, A. / Barton, N. / Bantscheff, M. / Bergamini, G. / Bertrand, S.M. / Convery, M. / Down, K. / Dumpelfeld, B. / Edwards, C.D. ...Henley, Z.A. / Amour, A. / Barton, N. / Bantscheff, M. / Bergamini, G. / Bertrand, S.M. / Convery, M. / Down, K. / Dumpelfeld, B. / Edwards, C.D. / Grandi, P. / Gore, P.M. / Keeling, S. / Livia, S. / Mallett, D. / Maxwell, A. / Price, M. / Rau, C. / Reinhard, F.B.M. / Rowedder, J. / Rowland, P. / Taylor, J.A. / Thomas, D.A. / Hessel, E.M. / Hamblin, J.N. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.4 Å |
Structure data | ![]() PDB-6tnr: ![]() PDB-6tns: |
Chemicals | ![]() ChemComp-NQ2: ![]() ChemComp-HOH: ![]() ChemComp-NQ5: |
Source |
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![]() | TRANSFERASE / PI3 Kinase Structure based design |