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-Structure paper
Title | The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. |
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Journal, issue, pages | Nature, Vol. 585, Page 293-297, Year 2020 |
Publish date | Nov 7, 2019 (structure data deposition date) |
Authors | Slabicki, M. / Kozicka, Z. / Petzold, G. / Li, Y.D. / Manojkumar, M. / Bunker, R.D. / Donovan, K.A. / Sievers, Q.L. / Koeppel, J. / Suchyta, D. ...Slabicki, M. / Kozicka, Z. / Petzold, G. / Li, Y.D. / Manojkumar, M. / Bunker, R.D. / Donovan, K.A. / Sievers, Q.L. / Koeppel, J. / Suchyta, D. / Sperling, A.S. / Fink, E.C. / Gasser, J.A. / Wang, L.R. / Corsello, S.M. / Sellar, R.S. / Jan, M. / Gillingham, D. / Scholl, C. / Frohling, S. / Golub, T.R. / Fischer, E.S. / Thoma, N.H. / Ebert, B.L. |
External links | Nature / PubMed:32494016 |
Methods | X-ray diffraction |
Resolution | 3.46 Å |
Structure data | PDB-6td3: |
Chemicals | ChemComp-RC8: |
Source |
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Keywords | LIGASE / ubiquitin ligase kinase cyclin CDK |