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-Structure paper
| Title | Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 63, Page 4468-4483, Year 2020 |
| Publish date | Oct 15, 2019 (structure data deposition date) |
 Authors | Kettle, J.G. / Bagal, S.K. / Bickerton, S. / Bodnarchuk, M.S. / Breed, J. / Carbajo, R.J. / Cassar, D.J. / Chakraborty, A. / Cosulich, S. / Cumming, I. ...Kettle, J.G. / Bagal, S.K. / Bickerton, S. / Bodnarchuk, M.S. / Breed, J. / Carbajo, R.J. / Cassar, D.J. / Chakraborty, A. / Cosulich, S. / Cumming, I. / Davies, M. / Eatherton, A. / Evans, L. / Feron, L. / Fillery, S. / Gleave, E.S. / Goldberg, F.W. / Harlfinger, S. / Hanson, L. / Howard, M. / Howells, R. / Jackson, A. / Kemmitt, P. / Kingston, J.K. / Lamont, S. / Lewis, H.J. / Li, S. / Liu, L. / Ogg, D. / Phillips, C. / Polanski, R. / Robb, G. / Robinson, D. / Ross, S. / Smith, J.M. / Tonge, M. / Whiteley, R. / Yang, J. / Zhang, L. / Zhao, X. |
 External links | J. Med. Chem. / PubMed:32023060 |
| Methods | X-ray diffraction |
| Resolution | 1.31 - 1.72 Å |
| Structure data |  PDB-6t5b:  PDB-6t5u:  PDB-6t5v: |
| Chemicals |  ChemComp-MG:  ChemComp-GDP:  ChemComp-O7K:  ChemComp-SO4:  ChemComp-HOH:  ChemComp-MKW:  ChemComp-MKZ: |
| Source |
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 Keywords | SIGNALING PROTEIN / GTPase |
homo sapiens (human)