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-Structure paper
Title | Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 126751-126751, Year 2020 |
Publish date | Oct 8, 2019 (structure data deposition date) |
![]() | Atkinson, B.N. / Steadman, D. / Mahy, W. / Zhao, Y. / Sipthorp, J. / Bayle, E.D. / Svensson, F. / Papageorgiou, G. / Jeganathan, F. / Frew, S. ...Atkinson, B.N. / Steadman, D. / Mahy, W. / Zhao, Y. / Sipthorp, J. / Bayle, E.D. / Svensson, F. / Papageorgiou, G. / Jeganathan, F. / Frew, S. / Monaghan, A. / Bictash, M. / Jones, E.Y. / Fish, P.V. |
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Methods | X-ray diffraction |
Resolution | 1.38 - 1.41 Å |
Structure data | ![]() PDB-6t2h: ![]() PDB-6t2k: |
Chemicals | ![]() ChemComp-DMS: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-NAG: ![]() ChemComp-M9N: ![]() ChemComp-HOH: ![]() ChemComp-M9K: |
Source |
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![]() | HYDROLASE / substrate |