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Structure paper

TitleStructural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Journal, issue, pagesNat Commun, Vol. 11, Page 2094-2094, Year 2020
Publish dateSep 4, 2019 (structure data deposition date)
AuthorsMagnussen, H.M. / Ahmed, S.F. / Sibbet, G.J. / Hristova, V.A. / Nomura, K. / Hock, A.K. / Archibald, L.J. / Jamieson, A.G. / Fushman, D. / Vousden, K.H. ...Magnussen, H.M. / Ahmed, S.F. / Sibbet, G.J. / Hristova, V.A. / Nomura, K. / Hock, A.K. / Archibald, L.J. / Jamieson, A.G. / Fushman, D. / Vousden, K.H. / Weissman, A.M. / Huang, D.T.
External linksNat Commun / PubMed:32350255
MethodsX-ray diffraction
Resolution1.21 - 2.18 Å
Structure data

PDB-6sqo:
Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub
Method: X-RAY DIFFRACTION / Resolution: 1.41 Å

PDB-6sqp:
Crystal structure of Cat MDM2-S429E RING domain homodimer
Method: X-RAY DIFFRACTION / Resolution: 1.21 Å

PDB-6sqr:
Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

PDB-6sqs:
Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-NO3:
NITRATE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • felis catus (domestic cat)
KeywordsLIGASE / Ubiquitin ligase / E3 / MDM2 / MDMX / E2 / phosphorylation / p53 / ubiquitin

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