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Structure paper

TitleStructural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 10, Page 1322-1327, Year 2019
Publish dateJul 26, 2019 (structure data deposition date)
AuthorsCollie, G.W. / Koh, C.M. / O'Neill, D.J. / Stubbs, C.J. / Khurana, P. / Eddershaw, A. / Snijder, A. / Mauritzson, F. / Barlind, L. / Dale, I.L. ...Collie, G.W. / Koh, C.M. / O'Neill, D.J. / Stubbs, C.J. / Khurana, P. / Eddershaw, A. / Snijder, A. / Mauritzson, F. / Barlind, L. / Dale, I.L. / Shaw, J. / Phillips, C. / Hennessy, E.J. / Cheung, T. / Narvaez, A.J.
External linksAcs Med. Chem. Lett. / PubMed:31531204
MethodsX-ray diffraction
Resolution1.67 - 2.49 Å
Structure data

PDB-6sd9:
Crystal structure of wild-type cMET bound by foretinib
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-6sdc:
Crystal structure of D1228V cMET bound by foretinib
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

PDB-6sdd:
Crystal structure of D1228V cMET bound by BMS-777607
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-6sde:
Crystal structure of wild-type cMET bound by savolitinib
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-88Z:
N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

ChemComp-HOH:
WATER

ChemComp-353:
N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

ChemComp-GOL:
GLYCEROL

ChemComp-V0L:
volitinib / inhibitor*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / inhibitor

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