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Title | N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology. |
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Journal, issue, pages | Acs Chem Neurosci, Vol. 10, Page 4685-4695, Year 2019 |
Publish date | Jul 22, 2019 (structure data deposition date) |
Authors | Mollerud, S. / Hansen, R.B. / Pallesen, J. / Temperini, P. / Pasini, D. / Bornholt, J. / Nielsen, B. / Mamedova, E. / Chalupnik, P. / Paternain, A.V. ...Mollerud, S. / Hansen, R.B. / Pallesen, J. / Temperini, P. / Pasini, D. / Bornholt, J. / Nielsen, B. / Mamedova, E. / Chalupnik, P. / Paternain, A.V. / Lerma, J. / Diaz-delCastillo, M. / Andreasen, J.T. / Frydenvang, K. / Kastrup, J.S. / Johansen, T.N. / Pickering, D.S. |
External links | Acs Chem Neurosci / PubMed:31622082 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-6sbt: |
Chemicals | ChemComp-SO4: ChemComp-L5H: ChemComp-CL: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | MEMBRANE PROTEIN / kainate receptor ligand-binding domain / GluK1-S1S2 / antagonist |