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TitleA pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy.
Journal, issue, pagesCommun Biol, Vol. 3, Page 697-697, Year 2020
Publish dateMay 21, 2019 (structure data deposition date)
AuthorsManzo, G. / Hind, C.K. / Ferguson, P.M. / Amison, R.T. / Hodgson-Casson, A.C. / Ciazynska, K.A. / Weller, B.J. / Clarke, M. / Lam, C. / Man, R.C.H. ...Manzo, G. / Hind, C.K. / Ferguson, P.M. / Amison, R.T. / Hodgson-Casson, A.C. / Ciazynska, K.A. / Weller, B.J. / Clarke, M. / Lam, C. / Man, R.C.H. / Shaughnessy, B.G.O. / Clifford, M. / Bui, T.T. / Drake, A.F. / Atkinson, R.A. / Lam, J.K.W. / Pitchford, S.C. / Page, C.P. / Phoenix, D.A. / Lorenz, C.D. / Sutton, J.M. / Mason, A.J.
External linksCommun Biol / PubMed:33247193
MethodsNMR (solution)
Structure data

PDB-6rsf:
NMR structure of pleurocidin KR in SDS micelles
Method: SOLUTION NMR

PDB-6rsg:
NMR structure of pleurocidin VA in SDS micelles
Method: SOLUTION NMR

Source
  • pseudopleuronectes americanus (winter flounder)
KeywordsANTIMICROBIAL PROTEIN / AMP / pleurocidin analogue / winter flounder / SDS micelles / sequence optimization

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