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-Structure paper
Title | Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 19, Page 525-539, Year 2020 |
Publish date | May 15, 2019 (structure data deposition date) |
![]() | Kidger, A.M. / Munck, J.M. / Saini, H.K. / Balmanno, K. / Minihane, E. / Courtin, A. / Graham, B. / O'Reilly, M. / Odle, R. / Cook, S.J. |
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Methods | X-ray diffraction |
Resolution | 1.96 Å |
Structure data | ![]() PDB-6rq4: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-KE8: ![]() ChemComp-HOH: |
Source |
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![]() | SIGNALING PROTEIN / protein kinase ATP-binding site serine/threonine kinase |