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TitleCRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia.
Journal, issue, pagesBlood, Vol. 139, Page 2227-2239, Year 2022
Publish dateMay 15, 2019 (structure data deposition date)
AuthorsBennett, C. / Lawrence, M. / Guerrero, J.A. / Stritt, S. / Waller, A.K. / Yan, Y. / Mifsud, R.W. / Ballester-Beltran, J. / Baig, A. / Mueller, A. ...Bennett, C. / Lawrence, M. / Guerrero, J.A. / Stritt, S. / Waller, A.K. / Yan, Y. / Mifsud, R.W. / Ballester-Beltran, J. / Baig, A. / Mueller, A. / Mayer, L. / Warland, J. / Penkett, C.J. / Akbari, P. / Moreau, T. / Evans, A.L. / Mookerjee, S. / Hoffman, G.J. / Saeb-Parsy, K. / Adams, D.J. / Couzens, A.L. / Bender, M. / Erber, W.N. / Nieswandt, B. / Read, R.J. / Ghevaert, C.
External linksBlood / PubMed:35051265
MethodsX-ray diffraction
Resolution1.61 - 1.97 Å
Structure data

PDB-6rpx:
Cytokine receptor-like factor 3 C-terminus residues 174-442: native
Method: X-RAY DIFFRACTION / Resolution: 1.61 Å

PDB-6rpy:
Cytokine receptor-like factor 3 C-terminus residues 174-442: Hg-SAD derivative
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-6rpz:
Cytokine receptor-like factor 3 C-terminus residues 174-442: native collected with 1.7A wavelength
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-HG:
Unknown entry

Source
  • mus musculus (house mouse)
KeywordsBLOOD CLOTTING / platelet development / fibronectin domain / SPRY domain

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