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-Structure paper
Title | Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265PMutant Diffuse Large B Cell Lymphoma. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 9918-9930, Year 2019 |
Publish date | Apr 15, 2019 (structure data deposition date) |
Authors | Degorce, S.L. / Anjum, R. / Bloecher, A. / Carbajo, R.J. / Dillman, K.S. / Drew, L. / Halsall, C.T. / Lenz, E.M. / Lindsay, N.A. / Mayo, M.F. ...Degorce, S.L. / Anjum, R. / Bloecher, A. / Carbajo, R.J. / Dillman, K.S. / Drew, L. / Halsall, C.T. / Lenz, E.M. / Lindsay, N.A. / Mayo, M.F. / Pink, J.H. / Robb, G.R. / Rosen, A. / Scott, J.S. / Xue, Y. |
External links | J. Med. Chem. / PubMed:31622099 |
Methods | X-ray diffraction |
Resolution | 2.31 - 2.61 Å |
Structure data | PDB-6rfi: PDB-6rfj: |
Chemicals | ChemComp-SO4: ChemComp-K1H: ChemComp-HOH: ChemComp-K1E: |
Source |
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Keywords | SIGNALING PROTEIN / IRAK4 / kinase / inhibitor / cancer |