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Structure paper

TitleBeating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 517-528, Year 2020
Publish dateMar 19, 2019 (structure data deposition date)
AuthorsSorensen, A.B. / Tuneew, I. / Svensson, L.A. / Persson, E. / Ostergaard, H. / Overgaard, M.T. / Olsen, O.H. / Gandhi, P.S.
External linksJ. Biol. Chem. / PubMed:31801825
MethodsX-ray diffraction
Resolution1.25 Å
Structure data

PDB-6r2w:
Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-TMA:
TETRAMETHYLAMMONIUM ION

ChemComp-0Z7:
N-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / TRYPSIN-FOLD / PROTEIN-PROTEIN COMPLEX / COAGULATION FACTOR

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