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-Structure paper
Title | Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 7897-7909, Year 2019 |
Publish date | Mar 8, 2019 (structure data deposition date) |
Authors | Buchstaller, H.P. / Anlauf, U. / Dorsch, D. / Kuhn, D. / Lehmann, M. / Leuthner, B. / Musil, D. / Radtki, D. / Ritzert, C. / Rohdich, F. ...Buchstaller, H.P. / Anlauf, U. / Dorsch, D. / Kuhn, D. / Lehmann, M. / Leuthner, B. / Musil, D. / Radtki, D. / Ritzert, C. / Rohdich, F. / Schneider, R. / Esdar, C. |
External links | J. Med. Chem. / PubMed:31381853 |
Methods | X-ray diffraction |
Resolution | 1.2 Å |
Structure data | PDB-6qxu: |
Chemicals | ChemComp-BME: ChemComp-JKN: ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / TANKYRASE / PARP / INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / TRANSFERASE |