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-Structure paper
Title | Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 178, Page 380-389, Year 2019 |
Publish date | Mar 7, 2019 (structure data deposition date) |
![]() | Ielo, L. / Deri, B. / Germano, M.P. / Vittorio, S. / Mirabile, S. / Gitto, R. / Rapisarda, A. / Ronsisvalle, S. / Floris, S. / Pazy, Y. ...Ielo, L. / Deri, B. / Germano, M.P. / Vittorio, S. / Mirabile, S. / Gitto, R. / Rapisarda, A. / Ronsisvalle, S. / Floris, S. / Pazy, Y. / Fais, A. / Fishman, A. / De Luca, L. |
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Methods | X-ray diffraction |
Resolution | 2.317 Å |
Structure data | ![]() PDB-6qxd: |
Chemicals | ![]() ChemComp-CU: ![]() ChemComp-JKB: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / Tyrosinase / Inhibitor / Ligand |