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-Structure paper
Title | The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. |
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Journal, issue, pages | Leukemia, Vol. 33, Page 2403-2415, Year 2019 |
Publish date | Feb 26, 2019 (structure data deposition date) |
![]() | Christian, S. / Merz, C. / Evans, L. / Gradl, S. / Seidel, H. / Friberg, A. / Eheim, A. / Lejeune, P. / Brzezinka, K. / Zimmermann, K. ...Christian, S. / Merz, C. / Evans, L. / Gradl, S. / Seidel, H. / Friberg, A. / Eheim, A. / Lejeune, P. / Brzezinka, K. / Zimmermann, K. / Ferrara, S. / Meyer, H. / Lesche, R. / Stoeckigt, D. / Bauser, M. / Haegebarth, A. / Sykes, D.B. / Scadden, D.T. / Losman, J.A. / Janzer, A. |
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Methods | X-ray diffraction |
Resolution | 1.52 Å |
Structure data | ![]() PDB-6qu7: |
Chemicals | ![]() ChemComp-ORO: ![]() ChemComp-FMN: ![]() ChemComp-JJE: ![]() ChemComp-SO4: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / DHODH |