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Title | Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 4656-4668, Year 2019 |
Publish date | Feb 8, 2019 (structure data deposition date) |
![]() | Karki, R.G. / Powers, J. / Mainolfi, N. / Anderson, K. / Belanger, D.B. / Liu, D. / Ji, N. / Jendza, K. / Gelin, C.F. / Mac Sweeney, A. ...Karki, R.G. / Powers, J. / Mainolfi, N. / Anderson, K. / Belanger, D.B. / Liu, D. / Ji, N. / Jendza, K. / Gelin, C.F. / Mac Sweeney, A. / Solovay, C. / Delgado, O. / Crowley, M. / Liao, S.M. / Argikar, U.A. / Flohr, S. / La Bonte, L.R. / Lorthiois, E.L. / Vulpetti, A. / Brown, A. / Long, D. / Prentiss, M. / Gradoux, N. / de Erkenez, A. / Cumin, F. / Adams, C. / Jaffee, B. / Mogi, M. |
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Methods | X-ray diffraction |
Resolution | 1.8 - 2 Å |
Structure data | ![]() PDB-6qmr: ![]() PDB-6qmt: |
Chemicals | ![]() ChemComp-J6T: ![]() ChemComp-HOH: ![]() ChemComp-J7B: |
Source |
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![]() | HYDROLASE / Complement factor D / inhibitor |